Assessment of genotype imputation performance using 1000 Genomes in African American studies.

Assessment of genotype imputation performance using 1000 Genomes in African American studies.

Genotype imputation, used in genome-wide association studies to expand coverage of single nucleotide polymorphisms (SNPs), has performed poorly in African Americans compared to less admixed populations. Overall, imputation has typically relied on HapMap reference haplotype panels from Africans (YRI)...

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Bibliographic Details
Main Authors: Dana B Hancock, Joshua L Levy, Nathan C Gaddis, Laura J Bierut, Nancy L Saccone, Grier P Page, Eric O Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511547?pdf=render

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http://europepmc.org/articles/PMC3511547?pdf=render

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