Epigenetic regulation of SST2 expression in small intestinal neuroendocrine tumors

Epigenetic regulation of SST2 expression in small intestinal neuroendocrine tumors

BackgroundSomatostatin receptor type 2 (SST2) expression is critical for the diagnosis and treatment of neuroendocrine tumors and is associated with improved patient survival. Recent data suggest that epigenetic changes such as DNA methylation and histone modifications play an important role in regu...

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Bibliographic Details
Main Authors: Maria J. Klomp, Julie Refardt, Peter M. van Koetsveld, Claudia Campana, Simone U. Dalm, Fadime Dogan, Marie-Louise F. van Velthuysen, Richard A. Feelders, Wouter W. de Herder, Johannes Hofland, Leo J. Hofland
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
DNA methylation
histone modifications
H3K27me3
H3K9ac
epigenetic
SI-NET
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1184436/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1184436/full

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