Establishment of Mouse Primed Stem Cells by Combination of Activin and LIF Signaling

Establishment of Mouse Primed Stem Cells by Combination of Activin and LIF Signaling

In mice, embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) are established from pre- and post-implantation embryos and represent the naive and primed state, respectively. Herein we used mouse leukemia inhibitory factor (LIF), which supports ESCs self-renewal and Activin A (Act A), which i...

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Bibliographic Details
Main Authors: Mengyi Wei, Yanglin Chen, Chaoyue Zhao, Li Zheng, Baojiang Wu, Chen Chen, Xihe Li, Siqin Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
primed stem cells
embryonic stem cells
conversion
Activin A
LIF
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.713503/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.713503/full

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