Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure

Regulation of Wnt Singaling Pathway by Poly (ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Lung Cancer in Mice Induced by Benzo(a)pyrene Inhalation Exposure

Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon that specifically causes cancer and is widely distributed in the environment. Poly (ADP-ribosylation), as a key post-translational modification in BaP-induced carcinogenesis, is mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) in e...

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Bibliographic Details
Main Authors: Wenjuan Dai, Yingbin Fu, Yanxia Deng, Zhuoying Zeng, Pan Gu, Hailong Liu, Jianjun Liu, Xinyun Xu, Desheng Wu, Xianru Luo, Linqing Yang, Jinzhou Zhang, Kai Lin, Gonghua Hu, Haiyan Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
benzo(a)pyrene
ADP-ribosylation
poly (ADP-ribose) glycohydrolase
Wnt signaling pathway
lung cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00338/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00338/full

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