KRAS and NRAS Translation Is Increased upon MEK Inhibitors-Induced Processing Bodies Dissolution

KRAS and NRAS Translation Is Increased upon MEK Inhibitors-Induced Processing Bodies Dissolution

Overactivation of the mitogen-activated protein kinase (MAPK) pathway is a critical driver of many human cancers. However, therapies directly targeting this pathway lead to cancer drug resistance. Resistance has been linked to compensatory RAS overexpression, but the mechanisms underlying this respo...

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Bibliographic Details
Main Authors: Olivia Vidal-Cruchez, Victoria J. Nicolini, Tifenn Rete, Karine Jacquet, Roger Rezzonico, Caroline Lacoux, Marie-Angela Domdom, Barnabé Roméo, Jérémie Roux, Arnaud Hubstenberger, Bernard Mari, Baharia Mograbi, Paul Hofman, Patrick Brest
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
liquid–liquid phase separation
MEK inhibitors
RAS oncogenic signaling
RNA metabolism
translation regulation
Online Access:https://www.mdpi.com/2072-6694/15/12/3078

Internet

https://www.mdpi.com/2072-6694/15/12/3078

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