A Novel Preclinical In Vitro 3D Model of Oral Carcinogenesis for Biomarker Discovery and Drug Testing

A Novel Preclinical In Vitro 3D Model of Oral Carcinogenesis for Biomarker Discovery and Drug Testing

This study aimed to develop an in vitro three-dimensional (3D) cell culture model of oral carcinogenesis for the rapid, scalable testing of chemotherapeutic agents. Spheroids of normal (HOK) and dysplastic (DOK) human oral keratinocytes were cultured and treated with 4-nitroquinoline-1-oxide (4NQO)....

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Bibliographic Details
Main Authors: Ravi Teja Chitturi Suryaprakash, Kate Shearston, Camile S. Farah, Simon A. Fox, Muhammad Munir Iqbal, Ulrich Kadolsky, Xiao Zhong, Alka Saxena, Omar Kujan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
oral squamous cell carcinoma
oral epithelial dysplasia
spheroid
chemoprevention
tobacco
alcohol
Online Access:https://www.mdpi.com/1422-0067/24/4/4096

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https://www.mdpi.com/1422-0067/24/4/4096

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