Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds

Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds

The pursuit of small molecule inhibitors targeting hexokinase 2 (HK2) has significantly captivated the field of cancer drug discovery. Nevertheless, the creation of selective inhibitors aimed at specific isoforms of hexokinase (HK) remains a formidable challenge. Here, we present a multiple-pharmaco...

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Bibliographic Details
Main Authors: Purbali Chakraborty, Syeda Lubna, Shouvik Bhuin, Deepika K., Manab Chakravarty, Trinath Jamma, Perumal Yogeeswari
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
oral cancer
hexokinase-2 inhibitor
pharmacophore
molecular dynamics
structure-based
mitochondria membrane potential
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1346270/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1346270/full

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