Activation of M1 muscarinic acetylcholine receptors by proline-rich oligopeptide 7a (<EDGPIPP) from Bothrops jararaca snake venom rescues oxidative stress-induced neurotoxicity in PC12 cells

Activation of M1 muscarinic acetylcholine receptors by proline-rich oligopeptide 7a (<EDGPIPP) from Bothrops jararaca snake venom rescues oxidative stress-induced neurotoxicity in PC12 cells

Abstract Background: The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability to prevent neuronal cell loss, injury, and death. Therefore, this study aimed to evaluate the cytoprotective...

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Bibliographic Details
Main Authors: Carlos Alberto-Silva, Halyne Queiroz Pantaleão, Brenda Rufino da Silva, Julio Cezar Araujo da Silva, Marcela Bermudez Echeverry
Format: Article
Language:English
Published: SciELO 2024-02-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Bothrops jararaca
Neuroprotection
Bioactive peptide
Proline-rich oligopeptide
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100302&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100302&tlng=en

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