SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA transcripts are also found in beta cells of p...

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Bibliographic Details
Main Authors: Alexis Z.L. Shih, Yi-Chun Chen, Thilo Speckmann, Esben Søndergaard, Annette Schürmann, C. Bruce Verchere, Thomas E. Willnow
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Molecular Metabolism
Subjects:
Beta cell
Endocytosis
IAPP
Islet amyloid
SORLA
VPS10P domain receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001545

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http://www.sciencedirect.com/science/article/pii/S2212877822001545

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