Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex

Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex

Summary: KRAS is widely mutated in human cancers, resulting in unchecked tumor proliferation and metastasis, which makes identifying KRAS-targeting therapies a priority. Herein, we observe that mutant KRAS specifically promotes the formation of the ERK2-p53 complex in stomach/colorectal tumor cells....

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Bibliographic Details
Main Authors: Xiang Wang, Qing Xie, Yan Ji, Jiaxin Yang, Jiayan Shen, Fangfei Peng, Yongfeng Zhang, Feng Jiang, Xiangyin Kong, Wenzhe Ma, Dandan Liu, Leizhen Zheng, Chen Qing, Jing-Yu Lang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722018769

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http://www.sciencedirect.com/science/article/pii/S2211124722018769

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