Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.

Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.

Expression and regulation of microRNAs is an emerging issue in erythroid differentiation and globin gene expression in hemoglobin disorders. In the first part of this study microarray analysis was performed both in mithramycin-induced K562 cells and erythroid precursors from healthy subjects or β-th...

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Main Authors: Nicoletta Bianchi, Alessia Finotti, Manuela Ferracin, Ilaria Lampronti, Cristina Zuccato, Giulia Breveglieri, Eleonora Brognara, Enrica Fabbri, Monica Borgatti, Massimo Negrini, Roberto Gambari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4388523?pdf=render

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http://europepmc.org/articles/PMC4388523?pdf=render

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