Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

AbstractContext Aryl hydrocarbon receptor (AhR) agonists are potential therapeutic agents for ulcerative colitis (UC). Indirubin (IDR), which is a natural AhR ligand approved for leukemia treatment, ameliorates dextran sulfate sodium (DSS)-induced colitis in mice. However, the therapeutic mechanisms...

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Bibliographic Details
Main Authors: Zhe Liu, Jin-ru Zhang, Yong-xiang Huang, Xue-ying Li, Hai-peng Zhu, Rui-yi Yang, Song Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Pharmaceutical Biology
Subjects:
Aryl hydrocarbon receptor (AhR)
hemoglobin (Hb)
interleukin-17A (IL-17A)
NLR family pyrin domain containing 3 (NLRP3)
nuclear factor-kappa B (NF-κB)
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2023.2233565

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https://www.tandfonline.com/doi/10.1080/13880209.2023.2233565

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