Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

AbstractContext Aryl hydrocarbon receptor (AhR) agonists are potential therapeutic agents for ulcerative colitis (UC). Indirubin (IDR), which is a natural AhR ligand approved for leukemia treatment, ameliorates dextran sulfate sodium (DSS)-induced colitis in mice. However, the therapeutic mechanisms...

Full description

Bibliographic Details
Main Authors:	Zhe Liu, Jin-ru Zhang, Yong-xiang Huang, Xue-ying Li, Hai-peng Zhu, Rui-yi Yang, Song Chen
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	Pharmaceutical Biology
Subjects:	Aryl hydrocarbon receptor (AhR) hemoglobin (Hb) interleukin-17A (IL-17A) NLR family pyrin domain containing 3 (NLRP3) nuclear factor-kappa B (NF-κB)
Online Access:	https://www.tandfonline.com/doi/10.1080/13880209.2023.2233565

Similar Items

From Suppressor T Cells to Regulatory T Cells: How the Journey that Began with the Discovery of the Toxic Effects of TCDD Led to Better Understanding of the Role of AhR in Immunoregulation
by: Narendra Prasad Singh, et al.
Published: (2020-10-01)

Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer?
by: Ivan Qi Han Ngui, et al.
Published: (2020-05-01)

Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome
by: Liang Yin, et al.
Published: (2021-05-01)

Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice
by: Heather M. Kahalehili, et al.
Published: (2021-01-01)

Formononetin Protects LPS-Induced Mastitis Through Suppressing Inflammation and Enhancing Blood-Milk Barrier Integrity via AhR-Induced Src Inactivation
by: Kaihe Xiang, et al.
Published: (2022-02-01)

An Increased Level of Aryl Hydrocarbon Receptor in Patients with Pancreatic Cancer
by: Sahar Masoudi, et al.
Published: (2019-01-01)

Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model
by: Hao Li, et al.
Published: (2019-11-01)

The aryl hydrocarbon receptor meets immunology: friend or foe? A little of both
by: Walker eJulliard, et al.
Published: (2014-10-01)

CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter
by: Martina Kunkl, et al.
Published: (2019-04-01)

LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC
by: Gregory Thomas, et al.
Published: (2020-11-01)

NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications
by: Xuhui Fang, et al.
Published: (2021-01-01)

Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-κB/AMPK Activation in Obese Mice Fed a High-Fat Diet
by: Eugene Chang
Published: (2022-09-01)

Isoforskolin Alleviates AECOPD by Improving Pulmonary Function and Attenuating Inflammation Which Involves Downregulation of Th17/IL-17A and NF-κB/NLRP3
by: Chuang Xiao, et al.
Published: (2021-07-01)

Dendritic cell vaccination, immune regulation and clinical outcomes in ovarian cancer
by: Hannah E Goyne, et al.
Published: (2013-11-01)

Inflammasomes—New Contributors to Blood Diseases
by: Jaromir Tomasik, et al.
Published: (2022-07-01)

Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation
by: Chloé Michaudel, et al.
Published: (2020-02-01)

Fraxetin ameliorates symptoms of dextran sulphate sodium-induced colitis in mice
by: Xiuxiu Sun, et al.
Published: (2024-01-01)

ILC3, a Central Innate Immune Component of the Gut-Brain Axis in Multiple Sclerosis
by: Đorđe Miljković, et al.
Published: (2021-04-01)

Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor
by: Alba De Juan, et al.
Published: (2021-05-01)

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation
by: Adaobi Amobi-McCloud, et al.
Published: (2021-04-01)

Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review
by: Rosa Direito, et al.
Published: (2023-06-01)

Examining the Aryl Hydrocarbon Receptor Network in the Placental Tissues of Pregnancies Complicated by Pre-Eclampsia: An Explorative Case–Control Analysis
by: Serena Xodo, et al.
Published: (2023-10-01)

The key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor
by: Jingwen Wu, et al.
Published: (2022-08-01)

N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response
by: Yan-Fang Jiao, et al.
Published: (2018-02-01)

Huoxiang Zhengqi alleviates azoxymethane/dextran sulfate sodium-induced colitis-associated cancer by regulating Nrf2/NF-κB/NLRP3 signaling
by: Mingyuan Dong, et al.
Published: (2022-10-01)

Dandelion polysaccharide treatment protects against dextran sodium sulfate‐induced colitis by suppressing NF‐κB/NLRP3 inflammasome‐mediated inflammation and activating Nrf2 in mouse colon
by: Shuo Wang, et al.
Published: (2023-11-01)

Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective effect against ulcerative colitis
by: Mona H. Zohny, et al.
Published: (2022-10-01)

Sacubitril/Valsartan Alleviates Experimental Autoimmune Myocarditis by Inhibiting Th17 Cell Differentiation Independently of the NLRP3 Inflammasome Pathway
by: Wei Liang, et al.
Published: (2021-09-01)

AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA
by: Zinah Zamil Al-Ghezi, et al.
Published: (2019-10-01)

Effects of Ginsenoside Rf on dextran sodium sulfate-induced colitis in mice
by: Sungeun Ahn, et al.
Published: (2021-01-01)

Preventive effect of Lacticaseibacillus rhamnosus 2016SWU.05.0601 and its postbiotic elements on dextran sodium sulfate-induced colitis in mice
by: Linli Bu, et al.
Published: (2024-02-01)

The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors
by: Maria L. Perepechaeva, et al.
Published: (2020-04-01)

A Novel Aryl Hydrocarbon Receptor Antagonist HBU651 Ameliorates Peripheral and Hypothalamic Inflammation in High-Fat Diet-Induced Obese Mice
by: Sora Kang, et al.
Published: (2022-11-01)

Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer
by: Leon J. S. Brokken, et al.
Published: (2013-02-01)

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90
by: Noriko Tsuji, et al.
Published: (2014-01-01)

Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling
by: Gerardo Vázquez-Gómez, et al.
Published: (2022-02-01)

TEST SYSTEM FOR EVALUATION OF THE INFLUENCE OF THE BIOLOGICAL ACTIVITY OF SUBSTANCES ON THE SIGNAL SYSTEM OF NF-κB: FOCUS ON THE DERIVATIVES OF 3-HYDROXYPYRIDINE
by: Sophiya Ya. Skachilova, et al.
Published: (2017-06-01)

Chronic exposure to low-level lipopolysaccharide dampens influenza-mediated inflammatory response via A20 and PPAR network
by: Yinuo Gu, et al.
Published: (2023-01-01)

Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia via the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1–NF-κB Pathway
by: Li Wang, et al.
Published: (2017-12-01)

Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways
by: Fangyuan Sun, et al.
Published: (2023-08-01)