Identification of Novel Alleles and Structural Haplotypes of Major Histocompatibility Complex Class I and DRB Genes in Domestic Cat (Felis catus) by a Newly Developed NGS-Based Genotyping Method

Identification of Novel Alleles and Structural Haplotypes of Major Histocompatibility Complex Class I and DRB Genes in Domestic Cat (Felis catus) by a Newly Developed NGS-Based Genotyping Method

The major histocompatibility complex (MHC) is a highly polymorphic and duplicated genomic region that encodes transplantation and immune regulatory molecules. Although it is well-known that particular MHC allelic polymorphisms and haplotypes are genetically relate to immune-mediated diseases detaile...

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Bibliographic Details
Main Authors: Masaharu Okano, Jiro Miyamae, Shingo Suzuki, Kohei Nishiya, Fumihiko Katakura, Jerzy K. Kulski, Tadaaki Moritomo, Takashi Shiina
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
domestic cat
major histocompatibility complex (MHC)
polymorphism
haplotype
next generation sequencing (NGS)
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00750/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00750/full

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