Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics

Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics

Abstract Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The F508del and G542X are the most common mutations found in US patients, accounting for 86.4% and 4.6% of all mutations, respectively. The F508del causes deletion of the...

Full description

Bibliographic Details
Main Authors: Iuri Viotti Perisse, Zhiqiang Fan, Arnaud Van Wettere, Ying Liu, Shih‐Hsing Leir, Jacob Keim, Misha Regouski, Michael D. Wilson, Kelly M. Cholewa, Sara N. Mansbach, Thomas J. Kelley, Zhongde Wang, Ann Harris, Kenneth L. White, Irina A. Polejaeva
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:FASEB BioAdvances
Subjects:
animal models
CFTR
cloning
CRISPR/Cas9
human drugs
Online Access:https://doi.org/10.1096/fba.2021-00043

Internet

https://doi.org/10.1096/fba.2021-00043

Similar Items