A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever

A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever

BackgroundIKBKE is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism of IKBKE (rs2297550-G) is a genome-wide association study risk variant of systemic lupus er...

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Bibliographic Details
Main Authors: Saeko Yamada, Yasuo Nagafuchi, Mamiko Yamada, Hisato Suzuki, Bunki Natsumoto, Mineto Ota, Ikuo Takazawa, Hiroaki Hatano, Masanori Kono, Hiroaki Harada, Hirofumi Shoda, Tomohisa Okamura, Kenjiro Kosaki, Keishi Fujio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
IKBKE
the inhibitor of κB kinase ϵ (IKKϵ)
rare variant
T cell
type I IFN
NFκB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475179/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475179/full

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