Role of the multi-drug efflux systems on the baseline susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam in clinical isolates of non-carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa

Role of the multi-drug efflux systems on the baseline susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam in clinical isolates of non-carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is one of the pathogens that urgently needs new drugs and new alternatives for its control. The primary strategy to combat this bacterium is combining treatments of beta-lactam with a beta-lactamase inhibitor. The most used combinations against P. a...

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Bibliographic Details
Main Authors: María José Contreras-Gómez, José R. W. Martinez, Lina Rivas, Roberto Riquelme-Neira, Juan A. Ugalde, Aniela Wozniak, Patricia García, José M. Munita, Jorge Olivares-Pacheco, Manuel Alcalde-Rico
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
ceftazidime/avibactam
cefotolozane/tazobactam
RND efflux pump
baseline susceptibility
carbapenem resistant Pseudomonas aeruginosa
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1007162/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1007162/full

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