Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with <i>GMCSF+IFN α </i> Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model

Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with <i>GMCSF+IFN α </i> Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model

This study evaluates a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains. BCG Tokyo > BCG TICE at i...

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Bibliographic Details
Main Authors: Sin Mun Tham, Juwita N. Rahmat, Edmund Chiong, Qinghui Wu, Kesavan Esuvaranathan, Ratha Mahendran
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
BCG Tokyo
combination of gene therapy and BCG
bladder cancer
antigen specific T cells
systemic immunity
Online Access:https://www.mdpi.com/2227-9059/9/12/1766

Internet

https://www.mdpi.com/2227-9059/9/12/1766

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