The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long...

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Podrobná bibliografie
Hlavní autoři: Philippa Marrack, Sai Harsha Krovi, Daniel Silberman, Janice White, Eleanor Kushnir, Maki Nakayama, James Crooks, Thomas Danhorn, Sonia Leach, Randy Anselment, James Scott-Browne, Laurent Gapin, John Kappler
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2017-11-01
Edice:eLife
Témata:
T cell receptor
major histocompatibility complex
CDR3 alpha
thymus
selection
On-line přístup:https://elifesciences.org/articles/30918

Internet

https://elifesciences.org/articles/30918

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