CAIX-Mediated Control of LIN28/<i>let-7</i> Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

CAIX-Mediated Control of LIN28/<i>let-7</i> Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

Solid tumors, including breast cancer, are characterized by the hypoxic microenvironment, extracellular acidosis, and chemoresistance. Hypoxia marker, carbonic anhydrase IX (CAIX), is a pH regulator providing a selective survival advantage to cancer cells through intracellular neutralization while f...

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Bibliographic Details
Main Authors: Adriana Gibadulinova, Petra Bullova, Hynek Strnad, Kamil Pohlodek, Dana Jurkovicova, Martina Takacova, Silvia Pastorekova, Eliska Svastova
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
carbonic anhydrase IX
hypoxia
LIN28/<i>let-7</i> axis
metabolism
Online Access:https://www.mdpi.com/1422-0067/21/12/4299

Internet

https://www.mdpi.com/1422-0067/21/12/4299

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