IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities

IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities

Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors. Crucial barriers to long-term CAR T cell success encompass lo...

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Bibliographic Details
Main Authors: Dennis Christoph Harrer, Valerie Bezler, Jordan Hartley, Wolfgang Herr, Hinrich Abken
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
CAR
IRF4
exhaustion
sensitivity
tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185618/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185618/full

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