Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout.

Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout.

BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β). Since neutrophils play a major role in gout we sought to determine whether their...

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Main Authors: Ioannis Mitroulis, Konstantinos Kambas, Akrivi Chrysanthopoulou, Panagiotis Skendros, Eirini Apostolidou, Ioannis Kourtzelis, Georgios I Drosos, Dimitrios T Boumpas, Konstantinos Ritis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3241704?pdf=render

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http://europepmc.org/articles/PMC3241704?pdf=render

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