Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion

Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion

Coiled-coil-helix-coiled-coil-helix domain-containing 10 (CHCHD10) is a nuclear-encoded mitochondrial protein which is primarily mutated in the spectrum of familial and sporadic amyotrophic lateral sclerosis (ALS)–frontotemporal dementia (FTD). Endogenous CHCHD10 levels decline in the brains of ALS–...

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Bibliographic Details
Main Authors: Tian Liu, Liam Wetzel, Zexi Zhu, Pavan Kumaraguru, Viraj Gorthi, Yan Yan, Mohammed Zaheen Bukhari, Aizara Ermekbaeva, Hanna Jeon, Teresa R. Kee, Jung-A Alexa Woo, David E. Kang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
CHCHD10
TDP-43
PINK1
PARL
mitophagy
Online Access:https://www.mdpi.com/2073-4409/12/24/2781

Internet

https://www.mdpi.com/2073-4409/12/24/2781

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