Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet‐induced obese mice

Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet‐induced obese mice

Abstract Aims/Introduction The mechanisms underlying the effect of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on aortic endothelial dysfunction in diet‐induced obesity are not clearly understood. This study investigated whether SGLT2 inhibition by luseogliflozin improved free fatty acid (FFA)...

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Bibliographic Details
Main Authors: Shigeru Kawade, Kazuma Ogiso, Sigfrid Casmir Shayo, Takahiko Obo, Aiko Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of Diabetes Investigation
Subjects:
Aortic endothelial dysfunction
Oxidative stress
Sodium‐glucose cotransporter 2
Online Access:https://doi.org/10.1111/jdi.13981

Internet

https://doi.org/10.1111/jdi.13981

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