Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions

Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions

Abstract Background Hepatitis C virus (HCV) is considered a worldwide health problem since it affects over 3% of the population and causes 300,000 fatalities per year. Chronic infection causes high morbidity and mortality in patients, leading to liver cirrhosis, hepatocellular carcinoma, fibrosis, l...

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Bibliographic Details
Main Authors: Stephen Ejeh, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi
Format: Article
Language:English
Published: SpringerOpen 2021-10-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Ligand-based design
HCV NS5B polymerase
Pharmacokinetic profiles
Online Access:https://doi.org/10.1186/s43094-021-00373-6

Internet

https://doi.org/10.1186/s43094-021-00373-6

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