Determinants of pH-Dependent Modulation of Translocation in Dermonecrotic G-Protein-Deamidating Toxins

Determinants of pH-Dependent Modulation of Translocation in Dermonecrotic G-Protein-Deamidating Toxins

Cytotoxic necrotizing factors from E. coli (CNF1, CNF2) and Yersinia (CNFy) share N-terminal sequence similarity with Pasteurella multocida toxin (PMT). This common N-terminal region harbors the receptor-binding and translocation domains that mediate uptake and delivery of the C-terminal catalytic c...

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Bibliographic Details
Main Authors: Tana L. Repella, Mengfei Ho, Brenda A. Wilson
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Toxins
Subjects:
cytotoxic necrotizing factor
Pasteurella multocida toxin
dermonecrotic toxin
endosomal acidification
intoxication
drug-delivery
toxin-based therapeutics
Online Access:http://www.mdpi.com/2072-6651/5/6/1167

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http://www.mdpi.com/2072-6651/5/6/1167

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