HSP70-Mediated NLRP3 Inflammasome Suppression Underlies Reversal of Acute Kidney Injury Following Extracellular Vesicle and Focused Ultrasound Combination Therapy

HSP70-Mediated NLRP3 Inflammasome Suppression Underlies Reversal of Acute Kidney Injury Following Extracellular Vesicle and Focused Ultrasound Combination Therapy

Acute kidney injury (AKI) is the abrupt loss of renal function, for which only supportive therapies exist. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have been shown to be therapeutically effective in treating AKI by spurring endogenous cell proliferation and survival while...

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Bibliographic Details
Main Authors: Mujib Ullah, Daniel D. Liu, Sravanthi Rai, Waldo Concepcion, Avnesh S. Thakor
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
inflammasome
heat shock protein
extracellular vesicles
focused ultrasound
mesenchymal stromal cells
acute kidney injury
Online Access:https://www.mdpi.com/1422-0067/21/11/4085

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https://www.mdpi.com/1422-0067/21/11/4085

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