Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction

Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction

Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction (<b>IUGR</b>) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that...

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Bibliographic Details
Main Authors: Rachel L. Gibbs, James A. Wilson, Rebecca M. Swanson, Joslyn K. Beard, Zena M. Hicks, Haley N. Beer, Eileen S. Marks-Nelson, Ty B. Schmidt, Jessica L. Petersen, Dustin T. Yates
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Metabolites
Subjects:
carbohydrate metabolism
developmental origins of health and disease
DOHaD
fetal programming
metabolic dysfunction
Online Access:https://www.mdpi.com/2218-1989/14/3/156

Internet

https://www.mdpi.com/2218-1989/14/3/156

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