Possible in vivo mechanisms involved in photodynamic therapy using tetrapyrrolic macrocycles

Possible in vivo mechanisms involved in photodynamic therapy using tetrapyrrolic macrocycles

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Photodynamic therapy (PDT) mediated by oxidative stress causes direct tumor cell damage as well as microvascular injury. To improve this treatment new photosensitizers are being synthesized and tested. We evaluated the effects of PDT with 5,10,15,20-tetrakis(4-methoxyphenyl)-porphyrin (TMPP) and its...

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Bibliographic Details
Main Authors: A.G. Filip, S. Clichici, D. Daicoviciu, R.M. Ion, C. Tatomir, L. Rogojan, I. Opris, T. Mocan, D. Olteanu, A. Muresan
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Photodynamic therapy
Oxidative stress
Apoptosis
Tetrapyrrolic macrocycles
Cytokines
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100008

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