WNT3a Signaling Inhibits Aromatase Expression in Breast Adipose Fibroblasts—A Possible Mechanism Supporting the Loss of Estrogen Responsiveness of Triple-Negative Breast Cancers

WNT3a Signaling Inhibits Aromatase Expression in Breast Adipose Fibroblasts—A Possible Mechanism Supporting the Loss of Estrogen Responsiveness of Triple-Negative Breast Cancers

Estrogen-dependent breast cancers rely on a constant supply of estrogens and expression of estrogen receptors. Local biosynthesis, by aromatase in breast adipose fibroblasts (BAFs), is their most important source for estrogens. Triple-negative breast cancers (TNBC) rely on other growth-promoting sig...

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Bibliographic Details
Main Authors: Alexander Kaiser, Gabriele Eiselt, Joachim Bechler, Otmar Huber, Martin Schmidt
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
aromatase
breast cancer
breast adipose fibroblast
Wnt signaling
LEF-1 (lymphoid enhancer binding factor 1)
TCF-4 (T-cell factor 4)
Online Access:https://www.mdpi.com/1422-0067/24/5/4654

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https://www.mdpi.com/1422-0067/24/5/4654

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