LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker

LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker

Abstract Long interspersed element 1 (LINE-1) retrotransposons are repetitive sequences that can move within the genome by an autonomous mechanism. To limit their mutagenic potential, benign cells restrict LINE-1 expression through molecular mechanisms such as DNA methylation and histone modificatio...

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Main Authors: Pamela R. de Santiago, Sho Sato, Stephanie J. Zhang, Meaghan C. Dougher, Kyle M. Devins, Agnes J. Bilecz, Sagar Rayamajhi, Gabriel Mingo, Hannah S. Rendulich, Yi Feng, Connie Wu, Martin S. Taylor, Yelena Zhuravlev, Euihye Jung, Dalia K. Omran, Tian-Li Wang, Ie-Ming Shih, Lauren E. Schwartz, Sarah Kim, Mark A. Morgan, Janos L. Tanyi, Kathleen H. Burns, Ernst Lengyel, Carlos Parra-Herran, Andrew K. Godwin, David R. Walt, Ronny Drapkin
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00849-1

Internet

https://doi.org/10.1038/s41698-025-00849-1

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