Alterations of fractional anisotropy throughout cortico-basal ganglia gray matter in a macaque model of Huntington’s Disease

Alterations of fractional anisotropy throughout cortico-basal ganglia gray matter in a macaque model of Huntington’s Disease

We recently generated a nonhuman primate (NHP) model of the neurodegenerative disorder Huntington's disease (HD) using adeno-associated viral vectors to express a fragment of mutant HTT protein (mHTT) throughout the cortico-basal ganglia circuit. Previous work by our group established that mHTT...

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Bibliographic Details
Main Authors: Alison R. Weiss, William A. Liguore, Kristin Brandon, Xiaojie Wang, Zheng Liu, Christopher D. Kroenke, Jodi L. McBride
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Neurobiology
Subjects:
Diffusion tensor imaging
Fractional anisotropy
Cortico-basal ganglia
Adeno-associated virus
Huntington's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2665945X23000189

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http://www.sciencedirect.com/science/article/pii/S2665945X23000189

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