Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomes

Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomes

Abstract Objectives This study aimed to comprehensively compare host responses of patients with bacterial sepsis and those with viral (COVID-19) sepsis by analyzing messenger RNA (mRNA) and microRNA (miRNA) profiles to shed light on their distinct pathophysiological mechanisms. Design Prospective ob...

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Bibliographic Details
Main Authors: Arisa Muratsu, Sayaka Oda, Shinya Onishi, Jumpei Yoshimura, Hisatake Matsumoto, Yuki Togami, Yumi Mitsuyama, Hiroshi Ito, Daisuke Okuzaki, Hiroshi Ogura, Jun Oda
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Virology Journal
Subjects:
COVID-19
PD-1 and PD-L1 cancer immunotherapy signaling pathways
Bacterial sepsis
Th1 signaling
Whole blood transcriptome
Online Access:https://doi.org/10.1186/s12985-024-02451-6

Internet

https://doi.org/10.1186/s12985-024-02451-6

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