Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

Huntington’s disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that leads to a polyglutamine (PQ) repeat in the huntingtin protein, which aggregates in the brain and periphery. Previously, we use...

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Bibliographic Details
Main Authors: Jonathan R. Roth, Ruan Carlos Macedo de Moraes, Brittney P. Xu, Savannah R. Crawley, Malghalara A. Khan, Girish C. Melkani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Huntington’s disease
aggregation
Htt-polyQ
rapamycin
locomotion
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223911/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223911/full

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