Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome

Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome

Down syndrome (DS) is the most frequent genetic cause of developmental abnormalities leading to intellectual disability. One notable phenomenon affecting the formation of nascent neural circuits during late developmental periods is developmental switch of GABA action from depolarizing to hyperpolari...

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Bibliographic Details
Main Authors: Larisa V. Lysenko, Jeesun Kim, Francisco Madamba, Anna A. Tyrtyshnaia, Aarti Ruparelia, Alexander M. Kleschevnikov
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
Developmental excitatory-to-inhibitory GABA switch
Multi-unit activity
MUA
Giant depolarizing potentials
GDP
Primary cultures
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300718

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http://www.sciencedirect.com/science/article/pii/S0969996118300718

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