Computational analysis of fusion protein of anti-HER2 scFv and alpha luffin: A new immunotoxin protein for HER2 positive cancers

Abstract The present study deals with the computational design and analysis of a novel fusion protein based on a single chain variable fragment that binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2) in breast cancer cells. Alpha luffin, a small ribosome inactivatin...

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Bibliographic Details
Main Authors: Farzaneh Barkhordari, Elham Rismani, Maryam Tabasinezhad, Saeme Asgari, Leila Nematollahi, Yeganeh Talebkhan
Format: Article
Language:English
Published: Universidade de São Paulo 2022-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100785&tlng=en