Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice

Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice

The onset and exacerbation of dementia have been observed in elderly patients with type 2 diabetes. However, the underlying mechanism remains unclear. In this study, we investigated the effects of aging on the cognitive function in a mouse model of type 2 diabetes. Pathogen-free KK-Ay/TaJcl mice wer...

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Bibliographic Details
Main Authors: Keiichi Hiramoto, Masashi Imai, Shota Tanaka, Kazuya Ooi
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Life
Subjects:
type 2 diabetes
advanced glycation end products
ionized calcium binding adapter protein 1
tumor necrosis factor-α
inducible nitric oxide synthase
Online Access:https://www.mdpi.com/2075-1729/13/7/1540

Internet

https://www.mdpi.com/2075-1729/13/7/1540

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