Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity

Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity

Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics. In this work, we established novel transgenic HepaRG...

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Bibliographic Details
Main Authors: Manuel Vlach, Nicolas Quesnot, Hélène Dubois-Pot-Schneider, Catherine Ribault, Yann Verres, Kilian Petitjean, Claudine Rauch, Fabrice Morel, Marie-Anne Robin, Anne Corlu, Pascal Loyer
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Sensors
Subjects:
HepaRG cells
cell-based biosensors
cytochromes P450
drug screening
hepatotoxicity
Online Access:https://www.mdpi.com/1424-8220/19/10/2245

Internet

https://www.mdpi.com/1424-8220/19/10/2245

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