Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis

Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis

Abstract Background Fibroblast-like synoviocytes (FLS) play a prominent role in rheumatoid synovitis and degradation of the extracellular matrix through the production of inflammatory cytokines and metalloproteinases (MMPs). Since animal models are frequently used for elucidating the disease mechani...

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Bibliographic Details
Main Authors: Camilla Ribeiro Lima Machado, Adriana Maria Kakehasi, Felipe Ferraz Dias, Gustavo Gomes Resende, Patrícia Gnieslaw de Oliveira, Ricardo Machado Xavier, Marcus Vinicius Melo de Andrade
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Advances in Rheumatology
Subjects:
Fibroblast-like synoviocytes
Rheumatoid arthritis
Collagen-induced arthritis
Signaling transduction
Interleukin-6
Metalloproteinases
Online Access:https://doi.org/10.1186/s42358-022-00281-0

Internet

https://doi.org/10.1186/s42358-022-00281-0

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