Pathologic Inflammation in Malnutrition Is Driven by Proinflammatory Intestinal Microbiota, Large Intestine Barrier Dysfunction, and Translocation of Bacterial Lipopolysaccharide

Pathologic Inflammation in Malnutrition Is Driven by Proinflammatory Intestinal Microbiota, Large Intestine Barrier Dysfunction, and Translocation of Bacterial Lipopolysaccharide

Acute malnutrition, or wasting, is implicated in over half of all deaths in children under five and increases risk of infectious disease. Studies in humans and preclinical models have demonstrated that malnutrition is linked to an immature intestinal microbiota characterized by increased prevalence...

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Bibliographic Details
Main Authors: Grace T. Patterson, Elvia Y. Osorio, Alex Peniche, Sara M. Dann, Erika Cordova, Geoffrey A. Preidis, Ji Ho Suh, Ichiaki Ito, Omar A. Saldarriaga, Michael Loeffelholz, Nadim J. Ajami, Bruno L. Travi, Peter C. Melby
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
malnutrition
inflammation
microbiota
lipopolysaccharide
intestinal barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.846155/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.846155/full

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