Rational Formulation of targeted ABT-737 nanoparticles by self-assembled polypeptides and designed peptides

Rational Formulation of targeted ABT-737 nanoparticles by self-assembled polypeptides and designed peptides

Here we present the development of nanoparticles (NPs) formulations specifically designed for targeting the antiapoptotic Bcl-2 proteins on the outer membrane of mitochondria with the drug agent ABT-737. The NPs which are self-assembled by the natural polypeptide poly gamma glutamic acid (ϒPGA) and...

Full description

Bibliographic Details
Main Authors: Polina Aibinder, Ifat Cohen-Erez, Hanna Rapaport
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Apoptosis
BCL-2
β-sheet peptides
Self-assembly
Drug delivery
Cytotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024021261

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024021261

Similar Items