Multilocus Genetic Profile Reflecting Low Dopaminergic Signaling Is Directly Associated with Obesity and Cardiometabolic Disorders Due to Antipsychotic Treatment

Multilocus Genetic Profile Reflecting Low Dopaminergic Signaling Is Directly Associated with Obesity and Cardiometabolic Disorders Due to Antipsychotic Treatment

Treatment with second-generation antipsychotics (SGAs) can cause obesity and other cardiometabolic disorders linked to D2 receptor (DRD2) and to genotypes affecting dopaminergic (DA) activity, within reward circuits. We explored the relationship of cardiometabolic alterations with single genetic pol...

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Bibliographic Details
Main Authors: Aurora Arrue, Olga Olivas, Leire Erkoreka, Francisco Jose Alvarez, Ainara Arnaiz, Noemi Varela, Ainhoa Bilbao, Jose-Julio Rodríguez, María Teresa Moreno-Calle, Estibaliz Gordo, Elena Marín, Javier Garcia-Cano, Estela Saez, Miguel Ángel Gonzalez-Torres, Mercedes Zumárraga, Nieves Basterreche
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
atypical antipsychotic
dopaminergic system
polymorphisms
multilocus genetic profile score
cardiometabolic disorders
Online Access:https://www.mdpi.com/1999-4923/15/8/2134

Internet

https://www.mdpi.com/1999-4923/15/8/2134

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