Role of macrophage-to-myofibroblast transition in chronic liver injury and liver fibrosis

Abstract Background Chronic liver injury contributes to liver fibrosis, which is characterized by the excessive deposition of extracellular matrix (ECM) components. ECM is mainly composed of myofibroblasts. Recently, macrophage-to-myofibroblasts transition (MMT), has been identified as a novel origi...

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Bibliographic Details
Main Authors: Suhong Xia, Yujie Huang, Yu Zhang, Mingyu Zhang, Kai Zhao, Ping Han, Dean Tian, Jiazhi Liao, Jingmei Liu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:European Journal of Medical Research
Subjects:
Online Access:https://doi.org/10.1186/s40001-023-01488-7