Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical relevance since they require the use of immunocompromised mice and/or are poo...

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Bibliographic Details
Main Authors: Soo-Hyun Kim, Richard P. Redvers, Lap Hing Chi, Xiawei Ling, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Ana Carolina Baptista Moreno Martin, Robin L. Anderson, Delphine Denoyer, Normand Pouliot
Format: Article
Language:English
Published: The Company of Biologists 2018-07-01
Series:Disease Models & Mechanisms
Subjects:
4T1Br4
Breast cancer
Brain metastasis
Syngeneic mouse model
Histone deacetylase inhibitor
Online Access:http://dmm.biologists.org/content/11/7/DMM034850

Internet

http://dmm.biologists.org/content/11/7/DMM034850

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