The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

Candida albicans causes severe invasive candidiasis. C. albicans infection requires the virulence factor candidalysin (CL) which damages target cell membranes. However, the mechanism that CL uses to permeabilize membranes is unclear. We reveal that CL forms membrane pores using a unique mechanism. U...

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Bibliographic Details
Main Authors: Charles M Russell, Katherine G Schaefer, Andrew Dixson, Amber LH Gray, Robert J Pyron, Daiane S Alves, Nicholas Moore, Elizabeth A Conley, Ryan J Schuck, Tommi A White, Thanh D Do, Gavin M King, Francisco N Barrera
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
atomic force microscopy
native mass spectrometry
mass photometry
Online Access:https://elifesciences.org/articles/75490

Internet

https://elifesciences.org/articles/75490

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