Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

<p>Abstract</p> <p>Background</p> <p>Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic...

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Bibliographic Details
Main Authors: Maubert Eric, Monaghan Daniel T, Jane David E, Lesept Flavie, Orset Cyrille, Montagne Axel, Jullienne Amandine, Vivien Denis, Ali Carine
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Molecular Neurodegeneration
Subjects:
Tissue plasminogen activator
GluN2D
UBP145
excitotoxicity
stroke
glutamatergic neurotransmission
Online Access:http://www.molecularneurodegeneration.com/content/6/1/68

Internet

http://www.molecularneurodegeneration.com/content/6/1/68

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