No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats

Introduction: We previously reported that malignant hypertension is associated with impaired capillary density of target organs. Here, we tested the hypothesis that stabilization of hypoxia-inducible factor (HIF) in a modified “preconditioning” approach prevents the development of malignant hyperten...

Full description

Bibliographic Details
Main Authors: Andrea Hartner, Thomas Dambietz, Nada Cordasic, Carsten Willam, Nicolai Burzlaff, Martin Brötsch, Christoph Daniel, Mario Schiffer, Kerstin Amann, Roland Veelken, Gunnar Schley, Karl F. Hilgers
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Physiology
Subjects:
capillarization
vascular lesions
malignant hypertension
HIF stabilization
renovascular
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1208105/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1208105/full

Similar Items