Protection of outbred mice against a vaginal challenge by a Chlamydia trachomatis serovar E recombinant major outer membrane protein vaccine is dependent on phosphate substitution in the adjuvant

Protection of outbred mice against a vaginal challenge by a Chlamydia trachomatis serovar E recombinant major outer membrane protein vaccine is dependent on phosphate substitution in the adjuvant

Chlamydia trachomatis is the most common bacterial sexually-transmitted pathogen for which there is no vaccine. We previously demonstrated that the degree of phosphate substitution in an aluminum hydroxide adjuvant in a TLR-4-based C. trachomatis serovar E (Ser E) recombinant major outer membrane pr...

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Bibliographic Details
Main Authors: Sukumar Pal, Salvador Fernando Ausar, Delia F. Tifrea, Chunmei Cheng, Scott Gallichan, Violette Sanchez, Luis M. de la Maza, Lucian Visan
Format: Article
Language:English
Published: Taylor & Francis Group 2020-10-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
chlamydia trachomatis
subunit vaccine
neutralizing antibody
outbreed cd-1 mice
aluminum hydroxide adjuvant
recombinant major outer membrane protein
ifn-γ
Online Access:http://dx.doi.org/10.1080/21645515.2020.1717183

Internet

http://dx.doi.org/10.1080/21645515.2020.1717183

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