Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK

Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK

Chronologically aging yeast cells are prone to adaptive regrowth, whereby mutants with a survival advantage spontaneously appear and re-enter the cell cycle in stationary phase cultures. Adaptive regrowth is especially noticeable with short-lived strains, including those defective for SNF1, the homo...

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Bibliographic Details
Main Authors: Nazif Maqani, Ryan D. Fine, Mehreen Shahid, Mingguang Li, Elisa Enriquez-Hesles, Jeffrey S. Smith
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-02-01
Series:Microbial Cell
Subjects:
Snf1
AMPK
Cyc8
Cat8
aging
yeast
chronological lifespan
TPR
Online Access:http://microbialcell.com/researcharticles/spontaneous-mutations-in-cyc8-and-mig1-suppress-the-short-chronological-lifespan-of-budding-yeast-lacking-snf1-ampk/

Internet

http://microbialcell.com/researcharticles/spontaneous-mutations-in-cyc8-and-mig1-suppress-the-short-chronological-lifespan-of-budding-yeast-lacking-snf1-ampk/

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