Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling

Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling

Abstract Background Almonertinib is a third-generation EGFR-TKI, and studies on its resistance mechanisms are lacking. Cancer-associated fibroblasts (CAFs) can influence resistance to targeted therapeutics, but their role and mechanism of action in relation to almonertinib resistance are unclear. Th...

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Bibliographic Details
Main Authors: Guohao Wei, Lingyao Fan, Xiaoyan Song, Wenzheng Zhou, Min Sun, Yan Sun, Yuhui Yao, Huihui Zhao, Fangfang Chen, Chuandong Zhu
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
EGFR-TKI
Almonertinib
Cancer-associated fibroblast
Glycolysis
Hexokinases II
Online Access:https://doi.org/10.1007/s12672-025-01974-w

Internet

https://doi.org/10.1007/s12672-025-01974-w

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